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Embryo Transfer (ET): Data Collection And Utilization
THIS PAGE CONTAINS A DRAFT OF INFORMATION BEING EVALUATED FOR INCLUSION AS AN OFFICIAL GUIDELINE
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UNDER CONSTRUCTION
Care should be taken when using observations from animals resulting from embryo transfer (ET) in genetic evaluations to ensure that sufficient knowledge about the recipient females is available and any potential preferential treatment is identified. Seedstock animals resulting from ET are potentially influential and reflect additional investment to achieve genetic progress. Therefore, maximizing the accuracy of genetic predictions early in the animals' lives by using the animals' own observations has increased importance. But for maternally influenced traits such as weaning weight knowledge of the recipients' breed composition, age, and other factors must be considered. Additionally, because of the increased investment, breeders are motivated to provide preferential treatment that must be accounted for. Genetic evaluation of birth weight and calving difficulty requires special considerations because of the potential influences of alternative ET technologies.
Recipient dam considerations
Effects on the phenotype due to the dam of the animal are present in traits measured up to weaning, but generally not seen on phenotypes measured post-weaning. These include both genetic and non-genetic effects. For animals produced using ET these maternal influences are due to the recipient dam, and not the embryo donor dam. Therefore, information on the recipient dam for these maternally influenced traits is necessary to reliably include the observations in genetic evaluation. Both age of the recipient dam and its breed composition will affect maternally influenced traits - i.e. weaning weight.
Ideally, pedigree information on the recipient would be important to include but is not always available, as recipients are often commercial females. Some organizations producing genetic evaluations will not use observations resulting from non-registered recipient females. Other organizations will allow the use of these observations when age and breed composition of the recipient is known.
Birth Weight
Researchers have reported effects of various embryo transfer technologies on birth weight.[1][2][3][4] Literature indicates that birth weight can vary according to whether the embryo was produced using in vivo or in vitro (IVF) fertilization, the type of medium used and incubation process (e.g., oxygen tension). In one study the calves produced using IVF were 10% heavier than calves born from artificial insemination.[5]. In another report, relatively small differences in the length of the incubation period had a significant impact on birth weight of calves.[6] There are even reports that the oxygen concentration in the incubator can have an effect on birth weight.[NEED CITATION HERE].
In an ideal world, capturing data on these variables would permit the utilization of birth weight data for genetic evaluation. However, collecting and recording these data is likely infeasible to reliably allow the use of birth weight and calving difficulty observations from ET calves. The literature also indicates that these effects have not been detected in traits measured later in life. The literature contains mixed reports of the impact of alternative embryo technologies on gestation length.
Recomendations
BIF recommends that observations from animals resulting from ET for traits that do not have maternal effects can be used in genetic evaluations as long as any preferential treatment is accounted for, if given, by assigning an appropriate contemporary group.
BIF recommends that observations from animals resulting from ET for traits that have maternal effects can be used in genetic evaluations as long as the recipient dam's age, and breed composition are available, and any preferential treatment may have been accounted for.
BIF recommends to not use birth weight and calving difficulty observations from animals resulting from ET
Citations
- ↑ Behboodi, E., G.B. Anderson, R.H. BonDurant, S.L. Cargill, B.R. Kreuscher, J.F. Medrano and J.D. Murray. 1995. Birth of large calves that developed from in vitro-derived bovine embryos. Theriogenology v44 p227-232.
- ↑ Numabe T., Oikawa T., Kikuchi T. and Horiuchi T. 2000. Birth weight and birth rate of heavy calves conceived by transfer of in vitro or in vivo produced bovine embryos. Animal Reproduction Science, 64 (1-2), pp. 13-20.
- ↑ H. Jacobsen, M. Schmidt, P. Holm, P.T. Sangild, G. Vajta, T. Greve, H. Callesen. 2000. Body dimensions and birth and organ weights of calves derived from in vitro produced embryos cultured with or without serum and oviduct epithelium cells. Theriogenology, v53, Issue 9 p1761-1769. ISSN 0093-691X. https://doi.org/10.1016/S0093-691X(00)00312-5.
- ↑ Luiz Sergio Almeida Camargo, Celio Freitas, Wanderlei Ferreira de Sa, Ademir de Moraes Ferreira, Raquel Varela Serapiao, João Henrique Moreira Viana. 2010. Gestation length, birth weight and offspring gender ratio of in vitro-produced Gyr (Bos indicus) cattle embryos/ Animal Reproduction Science. Volume 120, Issues 1–4, p10-15. ISSN 0378-4320. https://doi.org/10.1016/j.anireprosci.2010.02.013.
- ↑ A.M van Wagtendonk-de Leeuw, B.J.G Aerts, J.H.G den Daas. 1995. Abnormal offspring following in vitro production of bovine preimplantation embryos: A field study. Theriogenology. Volume 49, Issue 5, p883-894. ISSN 0093-691X.https://doi.org/10.1016/S0093-691X(98)00038-7.
- ↑ Yong-Soo Park, So-Seob Kim, Jae-Myeoung Kim, Hum-Dai Park, Myung-Dae Byun. 2005. The effects of duration of in vitro maturation of bovine oocytes on subsequent development, quality, and transfer of embryos. Theriogenology. Volume 64, Issue 1, Pages 123-134. ISSN 0093-691X. https://doi.org/10.1016/j.theriogenology.2004.11.012.
