Talk:Gene Edited Animal Data

Comments on new content

• I forced the TOC to be the 1st thing since the intro was long. Good intro
• Should information about the effort/status of any government approvals be included in the data?
• Should we rename the page "Gene Edited Animal Data"? That way it sorts to "G" in the master TOC

All good stuff. Bruce L. Golden (talk) 18:13, 11 October 2024 (UTC)

Should the recommendation to genotype offspring be extended to descendants, who may carry the edit? Wsnelling (talk) 18:53, 11 October 2024 (UTC)

Makes sense. But how far down the pedigree do you go? Recommendations? Bruce L. Golden (talk) 23:40, 11 October 2024 (UTC)

From a computing perspective does it matter how deep you go? Snewman (talk) 04:55, 12 October 2024 (UTC)

How about progeny of edit carriers? No need to worry about further tracking descendants who did not inherit the edit. Wsnelling (talk) 13:05, 16 October 2024 (UTC)

I like the idea of a section relative to government approvals, and maybe (as long as the list remains short or could redirect to another source with a longer list) include a list of edits that have regulatory approval. As someone who teaches a class with some of this content, it would be handy as both a resource for instructors and to direct students to the guidelines for this info. Maybe that's an abstraction from our goals, but it is something I would use. Mrolf (talk) 16:06, 21 November 2024 (UTC)

Re: Comments on new content -- Mspangler (talk) 14:16, 20 November 2024 (UTC)

Note that the only new part to this page is the small section I added Gene Edited Animals in Genetic Evaluations. The rest is original to what Alison wrote and we approved. We can certainly make the edits suggested but also provide comments, if any, on the new material.

Re: Re: Comments on new content -- Mrolf (talk) 16:12, 21 November 2024 (UTC)

Given kinship, pedigree- or genomic-based, is fundamental to genetic evaluations and there could be consequences of introducing the products of gene editing into routine genetic evaluations, particularly if the edit(s) confer changes to quantitative traits currently under evaluation or for traits that are genetically correlated to traits under evaluation.

I think this sentence needs to be edited. Maybe just remove Given from the front?

Re: Comments on new content -- Mrolf (talk) 16:03, 21 November 2024 (UTC)

One question I have is relative to the old info. How are we defining "novel DNA"? To me, that suggests we're not or couldn't introduce DNA from another species, only things already existing in bovine (which is suggested later in that paragraph), but also later in the paragraph, it references transgenes, which to me are novel DNA. But I guess it could be referencing unintended DNA insertions (like DNA surrounding the intended edit if a template is provided). Do we need to clarify?

Re: Re: Comments on new content -- Mspangler (talk) 16:24, 21 November 2024 (UTC)

I made Warren's suggested change of genotyping offspring of animals that carry the edit. I made Megan's change removing "Given". Bruce--How do I change the page title to follow your suggestion? Megan--To your comments on "novel" if you have suggestions on wording let us know.